a 2019 review of Bravecto and other flea and tick products containing isoxazoline revealed
: See Valerie Palmieri, et al., “Survey of Canine Use and Safety of Isoxazoline Parasiticides,” Vet Med Sci 6, no. 4 (November 2020): 933–45. doi: 10.1002/vms3.285. Epub 2020 Jun 2.
these substances are ubiquitous in the environment and have been detected at high levels in dog poop: See Jing Ma, Hongkai Zhu and Kurunthachalam Kannan, “Fecal Excretion of Perfluoroalkyl and Polyfluoroalkyl Substances in Pets from New York State, United States,” Environmental Science & Technology Letters 7, no. 3 (2020): 135–42. doi: 10.1021/acs.estlett.9b00786.
More than 80 percent of North Americans use some kind of air fresheners: See Grand View Reports’ summary of “U.S. Air Fresheners Market Analysis by Product Type (Aerosol/Spray, Electric Air Fresheners, Gels, Candles, Others) by Application (Residential, Commercial, Cars, Others), Competitive Analysis And Segment Forecasts, 2018 – 2025” at https://www.grandviewresearch.com/industry-analysis/us-air-fresheners-market. In it, the report says that according to a survey conducted by the Census data and Simmons National Consumer Survey (NHCS), “more than 80% of the U.S. population uses air freshener products, primarily for residential applications.”