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Chapter 8

Supplemental Habits for a Long and Healthy Life: The Essentials to Navigate Safe and Effective Supplements

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The global pet supplements market size was valued at $637.6 million in 2019 and is expected to grow at a compound annual growth rate of 6.4 percent from 2020 to 2027: See Grand View Research’s Market Analysis Report at

said they would take leave from work to care for a new pet if they could: See the AP’s press release from Business Wire, “Millennials Shower Pets with Financial Attention,” May 14, 2018,

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dog people spend four times as much on their furry friends as cat people and account for an estimated 78 percent of all pet supplement sales: Go to the American Pet Products Association at www.

cells have their own innate ability to generate antioxidant enzymes on demand: See Anil K. Jaiswal, “Nrf2 Signaling in Coordinated Activation of Antioxidant Gene Expression,” Free Radical Biology and Medicine 36, no. 10 (2004): 1199–1207.

Several natural compounds that turn on antioxidant and detoxification pathways have been identified: See N. Robledinos-Antón, R. Fernández-Ginés, G. Manda, and A. Cuadrado, “Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development,” Oxid Med Cell Longev 2019 (July 2019): 9372182. doi: 10.1155/2019/9372182.

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Maximizing Anti-Aging, Pro-longevity Actions in the Body: See Dr. Puya Yazdi’s terrific, well-cited blog post “All About mTOR + Natural mTOR Inhibitors & Activators” at on September 18, 2020,

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reduce risk for all manner of mind-related ailments, from depression to cognitive decline and dementia: See L. M. Mathew, et al., “Resveratrol Administration Increases Phagocytosis, Decreases Oxidative Burst, and Promotes Pro-inflammatory Cytokine Production in Healthy Dogs,” Vet Immunol Immunopathol 203, (September 2018): 21–29. doi: 10.1016/j.vetimm.2018.07.013. Epub 2018 Jul 30. PMID: 30243369.

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Without fatty acids, cells would simply fall apart: To access a variety of articles (and relevant studies) on EFAs, see ScienceDirect’s entry on the subject at

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need more of vitamins E and D, omega 3’s, and zinc to avoid nutritional dermatosis (skin problems): See A. Marchegiani, et al., “Impact of Nutritional Supplementation on Canine Dermatological Disorders,” Vet Sci 7, no. 2 (April 2020): 38. doi: 10.3390/vetsci7020038.

Quercetin is an important dietary polyphenol: See Rodney’s post “Nature’s Benadryl: Quercetin, at Dogs Naturally Magazine, November 20, 2020,

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It also inhibits AGE formation in the body: See Giancarlo Aldini, et al., “Molecular Strategies to Prevent, Inhibit, and Degrade Advanced Glycoxidation and Advanced Lipoxidation End Products,” Free Radic Res 47, Suppl 1 (August 2013): 93–137. doi: 10.3109/10715762.2013.792926. Epub 2013 May 7.

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a study in aging mice demonstrated that supplementing orally with nicotinamide mononucleotide (NMN), . . . prevented age-associated genetic changes: See Kathryn F. Mills, et al., “Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice,” Cell Metab 24, no. 6 (December 2016): 795–806. doi: 10.1016/j.cmet.2016.09.013. Epub 2016 Oct 27.

when NMN was given to Beagles experimentally . . . it also reduced lipid and insulin levels: See Yingnan You, et al., “Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration,” Front Pharmacol 11 (December 2020): 604404. doi: 10.3389/fphar.2020.604404. eCollection 2020.

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chronic stress can accelerate cognitive decline and impair memory function: See Rebecca Sussams, et al., “Psychological Stress, Cognitive Decline and the Development of Dementia in Amnestic Mild Cognitive Impairment,” Sci Rep 10, no. 1 (February 2020): 3618. doi: 10.1038/s41598-020-60607-0.

This nootropic mushroom: See Jayne Leonard’s entry (“What
Are the Benefits of Lion’s Mane Mushrooms?”) on Medical News Today for an overview of Lion’s Mane mushroom’s potential benefits and links to studies, October 22, 2018,

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That’s why glutathione is called the master antioxidant: For an overview of glutathione’s actions in the body, see Joseph Pizzorno, “Glutathione!” Integr Med (Encinitas) 13, no. 1 (February 2014): 8–12.

Low dose deprenyl (Selegiline) is the only FDA-approved treatment for canine cognitive dysfunction: Tamás Tábi, et al., “Selegiline: A Molecule with Innovative Potential,” J Neural Transm (Vienna) 127, no. 5 (May 2020): 831–42. doi: 10.1007/s00702-019-02082-0. Epub 2019 Sep 27.

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S-Adenosyl methionine (SAMe) is a naturally occurring molecule: For an overview of SAMe and key references, see its entry on the National Center for Complementary and Integrative Health’s website at

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Milk thistle (silymarin) is the go-to liver detox herb: For an overview of milk thistle and key references, see its entry on the National Center for Complementary and Integrative Health’s website at

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study involving eighty-one dogs with mild-to-moderate degenerative joint disease: See B. Pollard, W. G. Guilford, K. L. Ankenbauer-Perkins, and D. Hedderley, “Clinical Efficacy and Tolerance of an Extract of Green-lipped Mussel (Perna canaliculus) in Dogs Presumptively Diagnosed with Degenerative Joint Disease,” N Z Vet J 43, no. 3 (June 2006): 114–18. doi: 10.1080/00480169.2006.36622.

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L-theanine is a calming amino acid found primarily in tea: See Shinsuke Hidese, et al., “Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial,” Nutrients 11, no. 10 (October 2019): 2362. doi: 10.3390/nu11102362.

Ashwagandha, a small evergreen shrub: See Morgan A. Pratte, et al. “An Alternative Treatment for Anxiety: A Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania somnifera).” Journal of Alternative and Complementary Medicine (New York) 20, no. 12 (2014): 901–8. doi:10.1089/acm.2014.0177.

Bacopa monnieri is a staple plant used in Ayurvedic medicine: See Sebastian Aguiar and Thomas Borowski, “Neuropharmacological Review of the Nootropic Herb Bacopa monnieri,” Rejuvenation Res 16, no. 4 (August 2013): 313–26.

Rhodiola rosea is another adaptogenic herb that fortifies the body to better handle stress: See Sana Ishaque, Larissa Shamseer, Cecilia Bukutu, and Sunita Vohra, “Rhodiola rosea for Physical and Mental Fatigue: A Systematic Review,” BMC Complement Altern Med 12 (2012): 70.

lignans can be helpful in balancing remaining hormones if a dog has been desexed within the first year of life: For a review of lignans and their biological effects, see Oregon State University’s Linus Pauling Institute’s Micronutrient Information Center and access its entry on the subject;

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Carnosine . . . has been demonstrated to help prevent the body from absorbing and metabolizing AGEs and ALEs: See Giancarlo Aldini, et al., “Molecular Strategies to Prevent, Inhibit, and Degrade Advanced Glycoxidation and Advanced Lipoxidation End Products,” Free Radic Res 47, Suppl 1 (August 2013): 93–137. doi: 10.3109/10715762.2013.792926. Epub 2013 May 7.

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Chlorella . . . binds heavy metals and food and environmental contaminants: See Dan Wessels’s review of chlorella (“What Are the Health Benefits of Chlorella?”) for Medical News Today, November 6, 2019, at

Chemical Detox Supplements: See Aziza A El-Nekeety, et al., “Quercetin Inhibits the Cytotoxicity and Oxidative Stress in Liver of Rats Fed Aflatoxin-contaminated Diet,” Toxicol Rep 1 (June 2014): 319–29. doi: 10.1016/j.toxrep.2014.05.014. eCollection 2014. Also see Enrico Gugliandolo, et al., “Evaluation of Neuroprotective Effects of Quercetin against Aflatoxin B1-Intoxicated Mice,” Animals (Basel) 10, no. 5 (May 2020): 898. doi: 10.3390/ani10050898. Also see: Zinayyera Subhani, “Efficacy of Chlorella pyrenoidosa to Ameliorate the Hepatotoxic Effects of Aflatoxin B1 in Broiler Chickens,” Pakistan Veterinary Journal 38 (March 2018).

The extract from leaves of the olive plant: See Dr. Patricia Jordan’s entry (“Olive Leaf: The Holistic Alternative to Antibiotics”) on this plant at Dogs Naturally Magazine,

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canine cardiac patients are prescribed this supplement to slow the progression of congestive heart failure: See Dr. Judy Morgan’s entry on this subject (“Benefits of CoQ10 for Heart Disease”) on her site at.

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Supplements can be mixed in with food or hidden in a small meatball or a dab of almond butter or fresh cheese: See Ho-Eun Park, et al., “Effects of Queso Blanco Cheese Containing Bifidobacterium longum KACC 91563 on Fecal Microbiota, Metabolite and Serum Cytokine in Healthy Beagle Dogs,” Anaerobe 64 (August 2020): 102234. doi: 10.1016/j.anaerobe.2020.102234. Epub 2020 Jul 3. PMID: 32628995.